What are the benefits of alpha-ketoglutarate?

AKG (alpha-ketoglutarate) is used by cells during growth and in healing from injuries and other wounds , and is especially important in the healing of muscle tissue. A controlled study found that intravenous AKG prevented a decline in protein synthesis in the muscles of patients recovering from surgery.

>> Click to read more <<

Beside above, is AKG anti aging?

The molecule grabbed attention as a possible antiaging treatment in 2014, when researchers reported AKG could extend life span by more than 50% in tiny Caenorhabditis elegans worms. That’s on par with a low-calorie diet, which has been shown to promote healthy aging, but is hard for most people to stick with.

Moreover, how much AKG should I take? The doses of AKG in athletes vary from 1 to 15 grams a day. As a sports ergogenic aid, AKG should be taken 1000-3000 mg about 30 minutes before exercise. To enhance the effects of AKG, it is better to take 100-150 mg of vitamin B6 along with it. For exercise recovery, a higher dose of AKG (5000-10000 mg) is required.

Simply so, where does Alpha-ketoglutarate come from?

Abstract. Alpha-Ketoglutarate (AKG) is a biological substance that plays important roles in cell metabolism and physiology. AKG is synthesized from glucose or oxaloacetate plus pyruvate. As an intermediate of the tricarboxylic acid cycle, AKG is essential for the oxidation of fatty acids, amino acids, and glucose.

What does Alpha-ketoglutarate dehydrogenase do?

Alpha-ketoglutarate dehydrogenase (?-KGDH) is a highly regulated enzyme, which could determine the metabolic flux through the Krebs cycle. It catalyses the conversion of ?-ketoglutarate to succinyl-CoA and produces NADH directly providing electrons for the respiratory chain.

Is alpha-ketoglutarate a keto acid?

Its carboxylate, ?-ketoglutarate also called 2-oxoglutarate, is an important biological compound. It is the keto acid produced by deamination of glutamate, and is an intermediate in the Krebs cycle.

What is magnesium alpha-ketoglutarate?

Overview. Alpha-ketoglutarate is a chemical found in the body. People use it to make medicine. Alpha-ketoglutarate is used for kidney disease, intestinal and stomach disorders, and many other conditions but there is no good scientific evidence to support most of these uses.

Does AAKG really work?

A double-blind study gave trained weight lifters either 4 grams of AAKG or a placebo three times a day during an eight-week weight-training regimen. AAKG had no effect on body composition but did improve measures of strength and short-term power performance.

Should I take rapamycin?

First, rapamycin and everolimus are FDA-approved drugs, safe for human use. Since 1999, rapamycin has been used by millions of patients with no unexpected problems. One may suggest that rapamycin/everolimus are safe enough for very sick patients, not for healthy people.

Is AAKG better than L-arginine?

AAKG steadily releases arginine in the bloodstream while also decreasing loss of arginine in the digestion process. Pure arginine is very difficult target towards a specific part of the body since it is consumed in a burst. AAKG makes it easier to control the flow of arginine in the bloodstream.

Can Alpha ketoglutarate be used in gluconeogenesis?

The resultant 2-oxoglutarate (?-ketoglutarate) is converted to oxaloacetate (OAA) and then to phosphoenolpyruvate (PEP) which is then diverted into the gluconeogenic pathway.

Is arginine alpha-ketoglutarate safe?

The suggested dosage of arginine alpha-ketoglutarate ranges from 1.2 to 3.5 grams per tablet, taken 2 or 3 times a day on an empty stomach. The tablets should be taken preferably in the morning and at least 30 minutes before workouts. Up to 20 grams of L-arginine per day is considered safe and non-toxic [71].

Leave a Reply