Ageing refers to degenerative changes that occur in all organisms without any reference to death, while senescence refers to the developmental stage at which close to death’ symptoms becomes apparent.
In this regard, what is senescence and what is its role aging?
Senescence is a cellular response characterized by a stable growth arrest and other phenotypic alterations that include a proinflammatory secretome. Senescence plays roles in normal development, maintains tissue homeostasis, and limits tumor progression.
In this way, how does senescence affect aging?
Senescence can in turn drive the consequential aging hallmarks in response to damage: stem cell exhaustion and chronic inflammation. Other responses to damage, such as proteostatic dysfunction and nutrient signaling disruption, are also integrally linked with the senescence response.
What is the aging process called?
Gerontology is the scientific study of the process of aging. Geriatrics refers to health care delivery for the elderly. It is the branch of medicine that treats the conditions and diseases associated with aging and old age. Longevity refers to the duration of life of an individual.
Senescence occurs in three different scenarios: senescence due to normal aging; senescence due to age-related diseases, and senescence induced due to therapy (such as chemotherapy).
Cellular senescence is a complex response to stress that contributes to suppress cancer and to initialize mechanisms of repair after tissue injury. However, the accumulation of senescent cells is considered a hallmark of aging and is believed to contribute to the aging phenotype and to drive age-related pathologies.
When this occurs, the cells cease proliferation (known as growth arrest), in essence irreversibly. They often become resistant to cell-death signals (apoptosis resistance) and they acquire widespread changes in gene expression (altered gene expression). Together, these features comprise the senescent phenotype (Fig.